College Football Week 4 Schedule, Predictions & Scoreboard

Now we get to have some fun with conference play kicking in. From Northwestern at Indiana and Clemson and Cal on Friday night, to Texas at Tennessee and Illinois at Ohio State starting a huge Saturday, and with Ole Miss at Florida, Oklahoma at Georgia, Iowa at Michigan, Oregon at USC, Texas A&M at LSU, and … here’s the full schedule for all of the Week 4 games.

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ACC Week 4 Schedule

Straight Up: 33-8

Against the Spread: 22-19

Point Total: 25-16

Friday, September 25, 2026

Clemson at Cal

Game Time: 9:30 PM ET

TV: ESPN

Consensus Line: Cal -1.5, o/u: 50.5

Prediction: COMING

Final Score: COMING

Saturday, September 26, 2026

Wake Forest at Louisville

Game Time: 12:00 PM ET

TV: ESPN

Consensus Line: Louisville -12.5, o/u: 58.5

Prediction: COMING

Final Score: COMING

Bucknell at Pitt

Game Time: 12:00 PM ET

TV: ACC Network

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Virginia Tech at Boston College

Game Time: 12:00 PM ET

TV: ACC Network

Consensus Line: Boston College -14.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Central Arkansas at Florida State

Game Time: 3:00 PM ET

TV: ACC Network

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

William & Mary at Duke

Game Time: 3:30 PM ET

TV: ACC Network

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Delaware at Virginia

Game Time: 6:00 PM ET

TV: ACC Network

Consensus Line: Virginia -20.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Central Michigan at Miami

Game Time: 6:30 PM ET

TV: CW

Consensus Line: Miami -41.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

App State at NC State

Game Time: 7:30 PM ET

TV: ESPNU

Consensus Line: NC State -13.5, o/u: 55.5

Prediction: COMING

Final Score: COMING

Missouri State at SMU

Game Time: 9:00 PM ET

TV: ACC Network

Consensus Line: SMU -34.5, o/u: 58.5

Prediction: COMING

Final Score: COMING

Georgia Tech at Stanford

Game Time: 10:30 PM ET

TV: ESPN

Consensus Line: Georgia Tech -3.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

American Conference Week 4 Schedule

Straight Up: 33-6

Against the Spread: 23-16

Point Total: 23-16

Friday, September 25, 2026

Army at Temple

Game Time: 4:00 PM ET

TV: ESPN

Consensus Line: Army -3.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Navy at UAB

Game Time: 7:00 PM ET

TV: ESPN

Consensus Line: Navy -7.5, o/u: 51.5

Prediction: COMING

Final Score: COMING

Saturday, September 26, 2026

Colorado State at UTSA

Game Time: 12:00 PM ET

TV: ESPNU

Consensus Line: UTSA -12.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

North Carolina Central at East Carolina

Game Time: 4:00 PM ET

TV: ESPN+

N

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

USF at Bowling Green

Game Time: 5:00 PM ET

TV: ESPN+

Consensus Line: USF -17.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Louisiana at Charlotte

Game Time: 6:30 PM ET

TV: ESPN+

Consensus Line: Louisiana -10.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Southern Miss at Tulane

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: Tulane -18.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Houston Christian at North Texas

Game Time: 7:30 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Tulsa at Arkansas

Game Time: 8:00 PM ET

TV: SEC Network

Consensus Line: Arkansas -6.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

Rice at Fresno State

Game Time: 10:00 PM ET

TV: CW

Consensus Line: Fresno State -14.5, o/u: 44.5

Prediction: COMING

Final Score: COMING

Big Ten Week 4 Schedule

Straight Up: 44-7

Against the Spread: 32-19

Point Total: 32-19

Friday, September 25, 2026

Howard at Rutgers

Game Time: 7:00 PM ET

TV: BTN

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Northwestern at Indiana

Game Time: 8:00 PM ET

TV: FOX

Consensus Line: Indiana -21.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Saturday, September 26, 2026

Illinois at Ohio State

Game Time: 12:00 PM ET

TV: FOX

Consensus Line: Ohio State -27.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

UCLA at Maryland

Game Time: 1:30 PM ET

TV: BTN

Consensus Line: UCLA -1.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

Notre Dame at Purdue

Game Time: 2:00 PM ET

TV: Peacock

Consensus Line: Notre Dame -27.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

Iowa at Michigan

Game Time: 3:30 PM ET

TV: CBS

Consensus Line: Michigan -4.5, o/u: 37.5

Prediction: COMING

Final Score: COMING

Wisconsin at Penn State

Game Time: 5:00 PM ET

TV: Peacock

Consensus Line: Penn State -9.5, o/u: 45.5

Prediction: COMING

Final Score: COMING

Nebraska at Michigan State

Game Time: 5:00 PM ET

TV: BTN

Consensus Line: Nebraska -5.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Oregon at USC

Game Time: 7:30 PM ET

TV: NBC

Consensus Line: Oregon -2.5, o/u: 62.5

Prediction: COMING

Final Score: COMING

Minnesota at Washington

Game Time: 11:00 PM ET

TV: FOX

Consensus Line: Washington -8.5, o/u: 45.5

Prediction: COMING

Final Score: COMING

Big 12 Week 4 Schedule

Straight Up: 38-6

Against the Spread: 27-18

Point Total: 32-13

Sam Houston at Texas Tech

Game Time: 12:00 PM ET

TV: TNT

Consensus Line: Texas Tech -35.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Colorado at Baylor

Game Time: 12:00 PM ET

TV: ESPN2

Consensus Line: Baylor -10.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Utah at Iowa State

Game Time: 3:30 PM ET

TV: FOX

Consensus Line: Utah -7.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

TCU at UCF

Game Time: 3:30 PM ET

TV: FS1

Consensus Line: TCU -3.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Houston at Georgia Southern

Game Time: 4:00 PM ET

TV: ESPNU

Consensus Line: Houston -17.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Kansas State at Cincinnati

Game Time: 7:00 PM ET

TV: ESPN2

Consensus Line: Kansas State -6.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

Oklahoma State at West Virginia

Game Time: 7:00 PM ET

TV: FS1

Consensus Line: West Virginia -1.5, o/u: 59.5

Prediction: COMING

Final Score: COMING

Arizona at Washington State

Game Time: 7:30 PM ET

TV: CBS

Consensus Line: Arizona -10.5, o/u: 47.5

Prediction: COMING

Final Score: COMING

Conference USA Week 4 Schedule

Straight Up: 25-5

Against the Spread: 18-12

Point Total: 20-10

Thursday, September 24, 2026

Liberty at Coastal Carolina

Game Time: 7:30 PM ET

TV: ESPN

Consensus Line: Liberty -2.5, o/u: 51.5

Prediction: COMING

Final Score: COMING

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Saturday, September 26, 2026

Sam Houston at Texas Tech

Game Time: 12:00 PM ET

TV: TNT

Consensus Line: Texas Tech -35.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

New Mexico at New Mexico State

Game Time: 3:30 PM ET

TV: CBS Sports Network

Consensus Line: New Mexico -12.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Delaware at Virginia

Game Time: 6:00 PM ET

TV: ACC Network

Consensus Line: Virginia -20.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Long Island University at FIU

Game Time: 6:00 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Kennesaw State at Arkansas State

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: Arkansas State -4.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

Mercyhurst at Western Kentucky

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Middle Tennessee at Jacksonville State

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: Jacksonville State -8.5, o/u: 51.5

Prediction: COMING

Final Score: COMING

Florida Atlantic at ULM

Game Time: 8:00 PM ET

TV: ESPN+

Consensus Line: Florida Atlantic -13.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

Missouri State at SMU

Game Time: 9:00 PM ET

TV: ACC Network

Consensus Line: SMU -34.5, o/u: 58.5

Prediction: COMING

Final Score: COMING

College Football Independents Week 4 Schedule

Straight Up: 6-0

Against the Spread: 4-2

Point Total: 2-4

Notre Dame at Purdue

Game Time: 2:00 PM ET

TV: Peacock

Consensus Line: Notre Dame -27.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

MAC Week 4 Schedule

Straight Up: 38-3

Against the Spread: 27-14

Point Total: 29-12

San Diego State at Toledo

Game Time: 12:00 PM ET

TV: CBS Sports Network

Consensus Line: Toledo -2.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

UNLV at Akron

Game Time: 12:00 PM ET

TV: ESPN+

Consensus Line: UNLV -12.5, o/u: 50.5

Prediction: COMING

Final Score: COMING

Ball State at Kent State

Game Time: 12:00 PM ET

TV: ESPN+

Consensus Line: Kent State -3.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Lindenwood at Eastern Michigan

Game Time: 1:00 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Boise State at Western Michigan

Game Time: 3:30 PM ET

TV: ESPN2

Consensus Line: Boise State -7.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Robert Morris at Buffalo

Game Time: 3:30 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Stonehill at Ohio

Game Time: 3:30 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

USF at Bowling Green

Game Time: 5:00 PM ET

TV: ESPN+

Consensus Line: USF -17.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Central Michigan at Miami

Game Time: 6:30 PM ET

TV: CW

Consensus Line: Miami -41.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

UMass at Sacramento State

Game Time: 9:00 PM ET

TV: ESPN+

Consensus Line: UMass -5.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Mountain West Week 4 Schedule

Straight Up: 20-8

Against the Spread: 17-11

Point Total: 21-7

UNLV at Akron

Game Time: 12:00 PM ET

TV: ESPN+

Consensus Line: UNLV -12.5, o/u: 50.5

Prediction: COMING

Final Score: COMING

Northern Illinois at Georgia State

Game Time: 2:00 PM ET

TV: ESPN+

Consensus Line: Georgia State -9.5, o/u: 55.5

Prediction: COMING

Final Score: COMING

Hawaii at Wyoming

Game Time: 3:00 PM ET

TV: CW

Consensus Line: Hawaii -3.5, o/u: 45.5

Prediction: COMING

Final Score: COMING

New Mexico at New Mexico State

Game Time: 3:30 PM ET

TV: CBS Sports Network

Consensus Line: New Mexico -12.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Oregon State at UTEP

Game Time: 9:00 PM ET

TV: Mountain West

Consensus Line: Oregon State -11.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Air Force at Nevada

Game Time: 10:30 PM ET

TV: FS1

Consensus Line: Air Force -4.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Pac-12 Week 4 Schedule

Straight Up: 22-2

Against the Spread: 18-6

Point Total: 13-11

San Diego State at Toledo

Game Time: 12:00 PM ET

TV: CBS Sports Network

Consensus Line: Toledo -2.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Colorado State at UTSA

Game Time: 12:00 PM ET

TV: ESPNU

Consensus Line: UTSA -12.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

Boise State at Western Michigan

Game Time: 3:30 PM ET

TV: ESPN2

Consensus Line: Boise State -7.5, o/u: 48.5

Prediction: COMING

Final Score: COMING

Incarnate Word at Texas State

Game Time: 6:00 PM ET

TV: USA Network

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Arizona at Washington State

Game Time: 7:30 PM ET

TV: CBS

Consensus Line: Arizona -10.5, o/u: 47.5

Prediction: COMING

Final Score: COMING

Troy at Utah State

Game Time: 7:30 PM ET

TV: CBS Sports Network

Consensus Line: Utah State -2.5, o/u: 49.6

Prediction: COMING

Final Score: COMING

Oregon State at UTEP

Game Time: 9:00 PM ET

TV: Mountain West

Consensus Line: Oregon State -11.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Rice at Fresno State

Game Time: 10:00 PM ET

TV: CW

Consensus Line: Fresno State -14.5, o/u: 44.5

Prediction: COMING

Final Score: COMING

SEC Week 4 Schedule

Straight Up: 35-5

Against the Spread: 32-18

Point Total: 30-10

Texas at Tennessee

Game Time: 12:00 PM ET

TV: ABC

Consensus Line: Texas -3.5, o/u: 56.6

Prediction: COMING

Final Score: COMING

South Alabama at Kentucky

Game Time: 12:45 PM ET

TV: SEC Network

Consensus Line: Kentucky -20.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Oklahoma at Georgia

Game Time: 3:30 PM ET

TV: ESPN

Consensus Line: Georgia -13.5, o/u: 43.5

Prediction: COMING

Final Score: COMING

Ole Miss at Florida

Game Time: 3:30 PM ET

TV: ABC

Consensus Line: Florida -3.5, o/u: 60.5

Prediction: COMING

Final Score: COMING

Vanderbilt at Auburn

Game Time: 4:15 PM ET

TV: SEC Network

Consensus Line: Auburn -9.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

South Carolina at Alabama

Game Time: 7:00 PM ET

TV: ESPN

Consensus Line: Alabama -13.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Texas A&M at LSU

Game Time: 7:30 PM ET

TV: ABC

Consensus Line: LSU -9.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Missouri at Mississippi State

Game Time: 7:45 PM ET

TV: SEC Network

Consensus Line: Mississippi State -5.5, 59.5

Prediction: COMING

Final Score: COMING

Tulsa at Arkansas

Game Time: 8:00 PM ET

TV: SEC Network

Consensus Line: Arkansas -6.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

Sun Belt Week 4 Schedule

Straight Up: 36-5

Against the Spread: 22-19

Point Total: 32-9

Thursday, September 24, 2026

Liberty at Coastal Carolina

Game Time: 7:30 PM ET

TV: ESPN

Consensus Line: Liberty -2.5, o/u: 51.5

Prediction: COMING

Final Score: COMING

Saturday, September 26, 2026

South Alabama at Kentucky

Game Time: 12:45 PM ET

TV: SEC Network

Consensus Line: Kentucky -20.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

Northern Illinois at Georgia State

Game Time: 2:00 PM ET

TV: ESPN+

Consensus Line: Georgia State -9.5, o/u: 55.5

Prediction: COMING

Final Score: COMING

Gardner-Webb at Marshall

Game Time: 3:30 PM ET

TV: ESPN+

Consensus Line: COMING

Prediction: COMING

Final Score: COMING

Houston at Georgia Southern

Game Time: 4:00 PM ET

TV: ESPNU

Consensus Line: Houston -17.5, o/u: 54.5

Prediction: COMING

Final Score: COMING

James Madison at Old Dominion

Game Time: 6:00 PM ET

TV: ESPN+

Consensus Line: James Madison -5.5, o/u: 47.5

Prediction: COMING

Final Score: COMING

Louisiana at Charlotte

Game Time: 6:30 PM ET

TV: ESPN+

Consensus Line: Louisiana -10.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

Southern Miss at Tulane

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: Tulane -18.5, o/u: 52.5

Prediction: COMING

Final Score: COMING

Kennesaw State at Arkansas State

Game Time: 7:00 PM ET

TV: ESPN+

Consensus Line: Arkansas State -4.5, o/u: 53.5

Prediction: COMING

Final Score: COMING

Troy at Utah State

Game Time: 7:30 PM ET

TV: CBS Sports Network

Consensus Line: Utah State -2.5, o/u: 49.5

Prediction: COMING

Final Score: COMING

App State at NC State

Game Time: 7:30 PM ET

TV: ESPNU

Consensus Line: NC State -13.5, o/u: 55.5

Prediction: COMING

Final Score: COMING

Florida Atlantic at ULM

Game Time: 8:00 PM ET

TV: ESPN+

Consensus Line: Florida Atlantic -13.5, o/u: 57.5

Prediction: COMING

Final Score: COMING

Consensus line based on BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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This story was originally published September 22, 2026 at 1:03 AM.