Week 6 College Football Predictions: Expert Picks & Lines
Week 6 is loaded with interesting games, but it’s all about the massive showdowns. Georgia at Alabama is the headliner, but Oklahoma vs Texas is a big deal, UCLA at Oregon is huge, and Indiana gets a test at Nebraska. Here’s this week’s CFN Expert Picks for the biggest games.
Jump for each game
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Results So Far | * means will win, but not cover
Read more Why Bears Matchup Is Matt LaFleur’s Biggest Game as Packers Coach
Southern Miss at Troy
Game Preview and Prediction
Consensus Line: Troy -10.5
Big Game Ben: Troy
Andre Cherry: Troy*
Riley Donald: Troy
E: Troy
Pete Fiutak: Troy
John Kennedy: Troy
Jackson Langendorf: Troy
Andrew Margolick: Troy
Jake Margolick: Troy*
Doug Millen: Troy
Connor O’Gara: Troy
Johnny Rosenstein: Troy
Nick Shepkowski: Troy
Clucko the Chicken: Southern Miss
Consensus Pick: Troy
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Jacksonville State at Kennesaw State
Game Preview and Prediction
Consensus Line: Jacksonville State -3.5
Big Game Ben: Jacksonville State
Andre Cherry: Kennesaw State
Riley Donald: Kennesaw State
E: Kennesaw State
Pete Fiutak: Jacksonville State
John Kennedy: Jacksonville State
Jackson Langendorf: Jacksonville State
Andrew Margolick: Kennesaw State
Jake Margolick: Kennesaw State
Doug Millen: Jacksonville State
Connor O’Gara: Kennesaw State
Johnny Rosenstein: Jacksonville State*
Nick Shepkowski: Kennesaw State
Clucko the Chicken: Jacksonville State
Consensus Pick: Kennesaw State
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
New Mexico State at FIU
Game Preview and Prediction
Consensus Line: FIU -6.5
Big Game Ben: FIU*
Andre Cherry: FIU
Riley Donald: New Mexico State
E: FIU
Pete Fiutak: FIU
John Kennedy: FIU
Jackson Langendorf: New Mexico State
Andrew Margolick: FIU*
Jake Margolick: FIU
Doug Millen: FIU*
Connor O’Gara: FIU*
Johnny Rosenstein: FIU
Nick Shepkowski: FIU*
Clucko the Chicken: New Mexico State
Consensus Pick: FIU*
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
USF at UTSA
Game Preview and Prediction
Consensus Line: Liberty -13.5
Big Game Ben: UTSA
Andre Cherry: USF
Riley Donald: UTSA
E: UTSA*
Pete Fiutak: UTSA
John Kennedy: USF
Jackson Langendorf: USF
Andrew Margolick: COMING
Jake Margolick: UTSA*
Doug Millen: COMING
Connor O’Gara: UTSA*
Johnny Rosenstein: UTSA
Nick Shepkowski: COMING
Clucko the Chicken: USF
Consensus Pick: UTSA*
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Florida State at Louisville
Game Preview and Prediction
Consensus Line: Louisville -3.5
Big Game Ben: Louisville*
Andre Cherry: Louisville
Riley Donald: Louisville
E: Louisville
Pete Fiutak: Louisville
John Kennedy: Louisville
Jackson Langendorf: Louisville
Andrew Margolick: COMING
Jake Margolick: Florida State
Doug Millen: COMING
Connor O’Gara: Florida State
Johnny Rosenstein: Florida State
Nick Shepkowski: COMING
Clucko the Chicken: Louisville
Consensus Pick: Louisville
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Iowa at Washington
Game Preview and Prediction
Consensus Line: Washington -3.5
Big Game Ben: Washington
Andre Cherry: Washington
Riley Donald: Iowa
E: Iowa
Pete Fiutak: Iowa
John Kennedy: Washington
Jackson Langendorf: Washington
Andrew Margolick: COMING
Jake Margolick: Washington
Doug Millen: COMING
Connor O’Gara: Washington
Johnny Rosenstein: Washington
Nick Shepkowski: COMING
Clucko the Chicken: Iowa
Consensus Pick: Washington
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Iowa State at BYU
Game Preview and Prediction
Consensus Line: BYU -10.5
Big Game Ben: BYU
Andre Cherry: BYU*
Riley Donald: BYU
E: BYU
Pete Fiutak: BYU*
John Kennedy: BYU *
Jackson Langendorf: BYU
Andrew Margolick: COMING
Jake Margolick: BYU
Doug Millen: COMING
Connor O’Gara: BYU
Johnny Rosenstein: BYU*
Nick Shepkowski: COMING
Clucko the Chicken: BYU
Consensus Pick: BYU
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Indiana at Nebraska
Game Preview and Prediction
Consensus Line: Indiana -7.5
Big Game Ben: Indiana
Andre Cherry: Nebraska
Riley Donald: Indiana
E: Nebraska
Pete Fiutak: Indiana
John Kennedy: Indiana
Jackson Langendorf: Indiana
Andrew Margolick: COMING
Jake Margolick: Indiana*
Doug Millen: COMING
Connor O’Gara: Indiana
Johnny Rosenstein: Indiana
Nick Shepkowski: COMING
Clucko the Chicken: Nebraska
Consensus Pick: Indiana
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Texas A&M at Missouri
Game Preview and Prediction
Consensus Line: Missouri -3.5
Big Game Ben: Missouri
Andre Cherry: Missouri
Riley Donald: Missouri
E: Missouri
Pete Fiutak: Missouri
John Kennedy: Missouri
Jackson Langendorf: Texas A&M
Andrew Margolick: COMING
Jake Margolick: Missouri
Doug Millen: COMING
Connor O’Gara: Missouri*
Johnny Rosenstein: Missouri
Nick Shepkowski: COMING
Clucko the Chicken: Missouri
Consensus Pick: Missouri
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Arizona at West Virginia
Game Preview and Prediction
Consensus Line: Arizona -3.5
Big Game Ben: Arizona
Andre Cherry: West Virginia
Riley Donald: West Virginia
E: West Virginia
Pete Fiutak: West Virginia
John Kennedy: Arizona
Jackson Langendorf: Arizona
Andrew Margolick: COMING
Jake Margolick: Arizona
Doug Millen: COMING
Connor O’Gara: Arizona
Johnny Rosenstein: Arizona*
Nick Shepkowski: COMING
Clucko the Chicken: Arizona
Consensus Pick: Arizona*
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
South Carolina at Florida
Game Preview and Prediction
Consensus Line: Florida -13.5
Big Game Ben: Florida
Andre Cherry: South Carolina
Riley Donald: Florida*
E: Florida
Pete Fiutak: Florida
John Kennedy: Florida
Jackson Langendorf: Florida*
Andrew Margolick: COMING
Jake Margolick: Florida
Doug Millen: COMING
Connor O’Gara: Florida
Johnny Rosenstein: Florida
Nick Shepkowski: COMING
Clucko the Chicken: Florida
Consensus Pick: Florida
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Oklahoma vs Texas
Game Preview and Prediction
Consensus Line: Texas -8.5
Big Game Ben: Texas
Andre Cherry: Texas
Riley Donald: Texas
E: Texas
Pete Fiutak: Texas
John Kennedy: Texas
Jackson Langendorf: Texas
Andrew Margolick: COMING
Jake Margolick: Texas
Doug Millen: COMING
Connor O’Gara: Texas*
Johnny Rosenstein: Texas
Nick Shepkowski: COMING
Clucko the Chicken: Texas
Consensus Pick: Texas
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Read more Filing in LIV Golf bankruptcy case features $300M investment from BC Partners
Stanford at Notre Dame
Game Preview and Prediction
Consensus Line: Notre Dame -37.5
Big Game Ben: Notre Dame
Andre Cherry: Notre Dame
Riley Donald: Notre Dame*
E: Notre Dame*
Pete Fiutak: Notre Dame
John Kennedy: Notre Dame
Jackson Langendorf: Notre Dame*
Andrew Margolick: COMING
Jake Margolick: Notre Dame
Doug Millen: COMING
Connor O’Gara: Notre Dame
Johnny Rosenstein: Notre Dame
Nick Shepkowski: COMING
Clucko the Chicken: Notre Dame
Consensus Pick: Notre Dame
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Ole Miss at Vanderbilt
Game Preview and Prediction
Consensus Line: Ole Miss -9.5
Big Game Ben: Ole Miss*
Andre Cherry: Ole Miss
Riley Donald: Ole Miss
E: Ole Miss
Pete Fiutak: Ole Miss
John Kennedy: Ole Miss
Jackson Langendorf: Ole Miss*
Andrew Margolick: COMING
Jake Margolick: Ole Miss
Doug Millen: COMING
Connor O’Gara: Ole Miss*
Johnny Rosenstein: Ole Miss
Nick Shepkowski: COMING
Clucko the Chicken: Vanderbilt
Consensus Pick: Ole Miss
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
UCLA at Oregon
Game Preview and Prediction
Consensus Line: Oregon -11.5
Big Game Ben: Oregon*
Andre Cherry: Oregon*
Riley Donald: Oregon
E: Oregon
Pete Fiutak: Oregon*
John Kennedy: Oregon
Jackson Langendorf: Oregon
Andrew Margolick: COMING
Jake Margolick: Oregon
Doug Millen: COMING
Connor O’Gara: Oregon
Johnny Rosenstein: Oregon
Nick Shepkowski: COMING
Clucko the Chicken: UCLA
Consensus Pick: Oregon
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Houston at Kansas State
Game Preview and Prediction
Consensus Line: Kansas State -2.5
Big Game Ben: Houston
Andre Cherry: Houston
Riley Donald: Houston
E: Kansas State
Pete Fiutak: Kansas State
John Kennedy: Kansas State
Jackson Langendorf: Kansas State
Andrew Margolick: COMING
Jake Margolick: Houston
Doug Millen: COMING
Connor O’Gara: Houston
Johnny Rosenstein: Houston
Nick Shepkowski: COMING
Clucko the Chicken: Houston
Consensus Pick: Houston
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
LSU at Kentucky
Game Preview and Prediction
Consensus Line: LSU -8.5
Big Game Ben: LSU
Andre Cherry: LSU*
Riley Donald: LSU
E: LSU*
Pete Fiutak: LSU
John Kennedy: LSU*
Jackson Langendorf: LSU*
Andrew Margolick: COMING
Jake Margolick: LSU
Doug Millen: COMING
Connor O’Gara: Kentucky
Johnny Rosenstein: LSU*
Nick Shepkowski: COMING
Clucko the Chicken: LSU
Consensus Pick: LSU*
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Georgia at Alabama
Game Preview and Prediction
Consensus Line: Alabama -1.5
Big Game Ben: Georgia
Andre Cherry: Georgia
Riley Donald: Georgia
E: Alabama
Pete Fiutak: Georgia
John Kennedy: Georgia
Jackson Langendorf: Georgia
Andrew Margolick: COMING
Jake Margolick: Georgia
Doug Millen: COMING
Connor O’Gara: Alabama
Johnny Rosenstein: Alabama
Nick Shepkowski: COMING
Clucko the Chicken: Alabama
Consensus Pick: Georgia
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
USC at Penn State
Game Preview and Prediction
Consensus Line: Penn State -1.5
Big Game Ben: Penn State
Andre Cherry: USC
Riley Donald: Penn State
E: USC
Pete Fiutak: USC
John Kennedy: USC
Jackson Langendorf: Penn State
Andrew Margolick: COMING
Jake Margolick: USC
Doug Millen: COMING
Connor O’Gara: Penn State
Johnny Rosenstein: USC
Nick Shepkowski: COMING
Clucko the Chicken: Penn State
Consensus Pick: USC
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Kansas at Utah
Game Preview and Prediction
Consensus Line: Utah -15.5
Big Game Ben: Utah
Andre Cherry: Utah
Riley Donald: Utah
E: Utah*
Pete Fiutak: Utah
John Kennedy: Utah
Jackson Langendorf: Utah*
Andrew Margolick: COMING
Jake Margolick: Utah
Doug Millen: COMING
Connor O’Gara: Utah
Johnny Rosenstein: Utah
Nick Shepkowski: COMING
Clucko the Chicken: Utah
Consensus Pick: Utah
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Boise State at Fresno State
Game Preview and Prediction
Consensus Line: Boise State -6.5
Big Game Ben: Boise State*
Andre Cherry: Boise State
Riley Donald: Boise State
E: Boise State
Pete Fiutak: Fresno State
John Kennedy: Boise State
Jackson Langendorf: Boise State
Andrew Margolick: COMING
Jake Margolick: Boise State
Doug Millen: COMING
Connor O’Gara: Boise State*
Johnny Rosenstein: Boise State*
Nick Shepkowski: COMING
Clucko the Chicken: Fresno State
Consensus Pick: Boise State
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Expert Picks Results So Far
Big Game Ben
SU: 87-25 ATS: 53-59
Andre Cherry
SU: 87-25 ATS: 56-56
Riley Donald
SU: 93-19 ATS: 61-51
E
SU: 87-25 ATS: 56-56
Pete Fiutak
SU: 85-27 ATS: 57-55
John Kennedy
SU: 88-24 ATS: 56-56
Jackson Langendorf
SU: 82-30 ATS: 58-54
Andrew Margolick
SU: 88-24 ATS: 49-63
Jake Margolick
SU: 87-25 ATS: 58-54
Doug Millen
SU: 92-20 ATS: 61-51
Connor O’Gara
SU: 88-24 ATS: 61-51
Johnny Rosenstein
SU: 85-27 ATS: 49-63
Nick Shepkowski
SU: 84-28 ATS: 52-60
Clucko the Chicken
SU: 48-84 ATS: 49-63
Consensus Pick
SU: 84-27 ATS: 55-57
USM at Troy | Jax St at Ken St | NMSU at FIU
USF at UTSA | FSU at UofL | Iowa at Wash
Iowa St at BYU | IU at Neb | TA&M at Mizzou
Arizona at WVU | SoCar at UF | OU vs Texas
Stan at ND | Ole Miss at Vandy | UCLA at UO
Houston at K-St | LSU at UK | UGa at Bama
USC at Penn St | KU at Utah | Boise at Fresno
Consensus line based on BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
Read more NHL roundup: Without Macklin Celebrini, Sharks blanked by Stars
Copyright 2026 The Arena Group, Inc. All Rights Reserved
This story was originally published October 6, 2026 at 1:18 AM.
Post Comment